In the BMBF-funded project “Integrated implementation of hybrid construction methods in series production – hypro”, a process chain (physical and virtual) for fibre-composite plastic-metal hybrid structures is being set up, which, due to its practical relevance, shows a competitive way of using hybrid materials in industrial applications. The core of this process chain is a flexible production cell using injection moulding combination technology, which allows a versatile and fully automated plasma-based pretreatment of a wide range of metallic materials before the subsequent direct injection moulding of thermoplastics. The continuous inline acquisition of process data in the tailored plant, tool and handling technology provides a comprehensive database for process analysis. Digitizing hybrid structures in development, characterization and production and combining real and simulation data enables calculation-supported non-destructive inline quality assurance and the prediction of component properties. Based on the virtual representation of the process chain, methods for the efficient design and layout of hybrid structures are developed. A total of ten partners are involved in the joint project, which started on May, 2020. Brose Fahrzeugteile SE & Co. KG, Bamberg is project coordinator.